The most important question we have to deal with is a combination of population control and the control of our environment - how to utilize the world in as effective a way as we can for the future of mankind.
Why are we here? I think many people assume, wrongly, that a company exists solely to make money. Money is an important part of a company's existence, if the company is any good. But a result is not a cause. We have to go deeper and find the real reason for our being.
I think that we must find some way to get more common sense, more rationality, in our decisions and less emotion.
Take risks. Ask big questions. Don't be afraid to make mistakes; if you don't make mistakes, you're not reaching far enough.