The most important ingredient for the success of any company is the quality of its people, starting with its leadership team.
I think dementia is the major healthcare threat to our economy and our security. It's a ticking time bomb - we have a whole generation of baby boomers that are going to age, many progressing to get Alzheimer's - which disproportionately affects women and minorities.
I would think the correlation between an era of increased globalization and an increased desire to participate in an entrepreneurial endeavor is not a coincidence. When interconnectedness is at a peak due to technological advances, the ability to spawn something new is slightly easier.