Our case, we used the organometallic compounds. Additionally, we need one important element, that is base. Without base, the acidic coupling reaction using organoboron compounds cannot proceed nicely. So, that is very important point in our cross-coupling reaction.
The coupling of aryl halides with copper at very high temperature is called the Ullmann reaction, which is of broad scope and has been used to prepare many symmetrical biaryls. However, when a mixture of two different aryl halides is used, there are three possible biaryl products.
